The hosts have run out of steam in their bid to finish in the top four, and they face a squad that is only two points below them.
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On Sunday, West Ham and Wolves will face off in a match for a place in Europe next season.
Andriy Yarmolenko will be out due to David Moyes' decision to give him time off due to Russia's invasion of Ukraine, while Vladimir Coufal is out injured following a hernia procedure.
Angelo Ogbonna and Arthur Masuaku had been away for a long time.
The hosts have won four games in a row in all competitions, with their previous setback coming against Manchester United on January 22.
Wolves, on the other hand, were thrashed by Arsenal in midweek but will be confident of taking something from the Hammers after winning two of their last three meetings with them.
The Hammers are now in sixth place in the Premier League, five points below the top four, while the visitors are only two points behind them.
Wolves have the third-best defensive record in the Premier League, and they'll be hoping to keep their European opponents at bay in London.
This is the 50th conference of the highest level. Wolves have 20 victories to West Ham's 18, with 11 ties.
Wolves, who won 1-0 in the reverse fixture earlier this season, may set a new club record by winning the Premier League against a single opponent for the seventh time.
West Ham has won just five of their past 15 Premier League matches, compared to seven of their opening 11 this season.
Premier League Odds
West Ham is on top at 2.05 as posted by bet365 Sports while Wolves are at 3.80. It will be a great chance for West Ham to make up some ground on its quest for Top 4 continues.